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  • In a study published in the journal Environmental Toxicology and Pharmacology in 2020, researchers examined the effects of food additives titanium dioxide and silica on the intestinal tract by grouping and feeding mice three different food-grade particles — micro-TiO2, nano-TiO2, and nano-SiO2.  With all three groups, researchers observed changes in the gut microbiota, particularly mucus-associated bacteria. Furthermore, all three groups experienced inflammatory damage to the intestine, but the nano-TiO2 displayed the most pronounced changes. The researchers wrote: “Our results suggest that the toxic effects on the intestine were due to reduced intestinal mucus barrier function and an increase in metabolite lipopolysaccharides which activated the expression of inflammatory factors downstream. In mice exposed to nano-TiO2, the intestinal PKC/TLR4/NF-κB signaling pathway was activated. These findings will raise awareness of toxicities associated with the use of food-grade TiO2 and SiO2.”

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  • Titanium dioxide, commonly known as titanium white, is a widely used pigment that imparts a brilliant white color to various products. It is an inorganic compound with the chemical formula TiO2 and is derived from titanium ore. This versatile material has a range of applications across multiple industries due to its unique properties such as high brightness, excellent whiteness, and chemical stability.
  • The most significant uncertainty identified by the EU experts was the concern that TiO2 particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO2 particles in E171 are genotoxic, they could not rule out the concern that they might be.

  • X-ray fluorescence spectroscopy (XRF) is a non-destructive technique that can be used to determine barium in TiO2determination of barium as tio2 factory. This method involves bombarding the sample with X-rays and measuring the resulting fluorescence spectrum. XRF offers fast analysis times and requires minimal sample preparation, making it suitable for on-site testing. However, its accuracy may be affected by matrix effects and interference from other elements.
  • Lithopone 28B301 and 30B311 A Comprehensive Guide for Manufacturers